There are three different ways to create dentures:
No. If your denture is constructed properly you should never have to use denture adhesive! Denture adhesives contain harmful substances like silicone that can really do some damage on your body like digestive disorders and other more serious health problems.
If you have trouble keeping a denture in place, even with adhesive, then maybe dentures aren’t the solution for you. Dental implants might be a better option. With just a few implants the upper and/or lower jaw can be stabilized and be able to retain a denture again.